{"ranking":[{"molecule":"rivaroxaban","display":"Rivaroxaban","rxcui":"1114195","atc":"B01AF01","atc_l1":"B","atc_l1_name":"Blood and blood forming organs","atc_l2":"B01","atc_l2_name":"Antithrombotic agents","brand_examples":["Xarelto"],"us_spend_2024_usd":6232231839.7,"us_units_2024":360337521,"us_benes_2024":1321019,"us_avg_cost_per_unit_usd":17.2955,"ca_price_per_unit_cad":0.355,"ca_unit":"unit","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per unit, Apo-Rivaroxaban 2.5mg Tab","ca_price_din":"02541734","ca_per_unit_usd":0.2592,"gap_usd_per_unit":17.04,"ratio_us_to_ca":66.73},{"molecule":"latanoprostene bunod","display":"Latanoprostene Bunod","rxcui":"1988390","atc":"S01EE06","atc_l1":"S","atc_l1_name":"Sensory organs","atc_l2":"S01","atc_l2_name":"Ophthalmologicals","brand_examples":["Vyzulta"],"us_spend_2024_usd":128286737.76,"us_units_2024":1297947,"us_benes_2024":75825,"us_avg_cost_per_unit_usd":98.8382,"ca_price_per_unit_cad":2.1,"ca_unit":"mL","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per mL, Vyzulta 0.024%w/v Oph Sol","ca_price_din":"02484218","ca_per_unit_usd":1.5331,"gap_usd_per_unit":97.31,"ratio_us_to_ca":64.47},{"molecule":"dapagliflozin propanediol","display":"Dapagliflozin Propanediol","rxcui":"1486966","atc":null,"atc_l1":null,"atc_l1_name":null,"atc_l2":null,"atc_l2_name":null,"brand_examples":["Dapagliflozin","Farxiga"],"us_spend_2024_usd":5492482710.54,"us_units_2024":301297661,"us_benes_2024":1492285,"us_avg_cost_per_unit_usd":18.2294,"ca_price_per_unit_cad":0.522,"ca_unit":"unit","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per unit, Accel-Dapagliflozin 10mg Tab","ca_price_din":"02543192","ca_per_unit_usd":0.3811,"gap_usd_per_unit":17.85,"ratio_us_to_ca":47.83},{"molecule":"bimatoprost","display":"Bimatoprost","rxcui":"283810","atc":"S01EE03","atc_l1":"S","atc_l1_name":"Sensory organs","atc_l2":"S01","atc_l2_name":"Ophthalmologicals","brand_examples":["Bimatoprost*","Durysta","Lumigan"],"us_spend_2024_usd":655739802.46,"us_units_2024":7065183,"us_benes_2024":357398,"us_avg_cost_per_unit_usd":92.8129,"ca_price_per_unit_cad":3.0645,"ca_unit":"mL","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per mL, Vistitan 0.03% Oph Sol","ca_price_din":"02429063","ca_per_unit_usd":2.2372,"gap_usd_per_unit":90.58,"ratio_us_to_ca":41.49},{"molecule":"canagliflozin","display":"Canagliflozin","rxcui":"1373458","atc":"A10BK02","atc_l1":"A","atc_l1_name":"Alimentary tract and metabolism","atc_l2":"A10","atc_l2_name":"Drugs used in diabetes","brand_examples":["Invokana"],"us_spend_2024_usd":272062235.32,"us_units_2024":14644180,"us_benes_2024":55993,"us_avg_cost_per_unit_usd":18.5782,"ca_price_per_unit_cad":0.7228,"ca_unit":"unit","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per unit, Apo-Canagliflozin 100mg Tab","ca_price_din":"02564556","ca_per_unit_usd":0.5277,"gap_usd_per_unit":18.05,"ratio_us_to_ca":35.21},{"molecule":"apixaban","display":"Apixaban","rxcui":"1364430","atc":"B01AF02","atc_l1":"B","atc_l1_name":"Blood and blood forming organs","atc_l2":"B01","atc_l2_name":"Antithrombotic agents","brand_examples":["Eliquis"],"us_spend_2024_usd":20774929225,"us_units_2024":2156238529,"us_benes_2024":4424796,"us_avg_cost_per_unit_usd":9.6348,"ca_price_per_unit_cad":0.4084,"ca_unit":"unit","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per unit, Ach-Apixaban 5mg Tab","ca_price_din":"02487721","ca_per_unit_usd":0.2981,"gap_usd_per_unit":9.34,"ratio_us_to_ca":32.32},{"molecule":"sitagliptin phosphate","display":"Sitagliptin Phosphate","rxcui":"621590","atc":null,"atc_l1":null,"atc_l1_name":null,"atc_l2":null,"atc_l2_name":null,"brand_examples":["Januvia"],"us_spend_2024_usd":3807854661.8,"us_units_2024":211984298,"us_benes_2024":828288,"us_avg_cost_per_unit_usd":17.9629,"ca_price_per_unit_cad":0.8197,"ca_unit":"unit","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per unit, Ach-Sitagliptin 100mg Tab","ca_price_din":"02512491","ca_per_unit_usd":0.5984,"gap_usd_per_unit":17.36,"ratio_us_to_ca":30.02},{"molecule":"travoprost","display":"Travoprost","rxcui":"283809","atc":"S01EE04","atc_l1":"S","atc_l1_name":"Sensory organs","atc_l2":"S01","atc_l2_name":"Ophthalmologicals","brand_examples":["Travatan Z","Travoprost"],"us_spend_2024_usd":85713207.13,"us_units_2024":2569289,"us_benes_2024":122995,"us_avg_cost_per_unit_usd":33.3607,"ca_price_per_unit_cad":1.576,"ca_unit":"mL","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per mL, IZBA 0.003% Oph Sol (with Preservative)","ca_price_din":"02457997","ca_per_unit_usd":1.1505,"gap_usd_per_unit":32.21,"ratio_us_to_ca":29},{"molecule":"pegfilgrastim","display":"Pegfilgrastim","rxcui":"338036","atc":"L03AA13","atc_l1":"L","atc_l1_name":"Antineoplastic and immunomodulating agents","atc_l2":"L03","atc_l2_name":"Immunostimulants","brand_examples":["Neulasta","Neulasta Onpro"],"us_spend_2024_usd":96273920.24,"us_units_2024":9341,"us_benes_2024":4336,"us_avg_cost_per_unit_usd":10307.0381,"ca_price_per_unit_cad":492,"ca_unit":"container","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per container, Niopeg 6mg/0.6mL Inj Sol-0.6mL Pref Syr (Preservative-Free)","ca_price_din":"02546973","ca_per_unit_usd":359.1765,"gap_usd_per_unit":9947.86,"ratio_us_to_ca":28.7},{"molecule":"mirabegron","display":"Mirabegron","rxcui":"1300786","atc":"G04BD12","atc_l1":"G","atc_l1_name":"Genito urinary system and sex hormones","atc_l2":"G04","atc_l2_name":"Urologicals","brand_examples":["Mirabegron ER","Myrbetriq"],"us_spend_2024_usd":2431374764.33,"us_units_2024":166998171,"us_benes_2024":881635,"us_avg_cost_per_unit_usd":14.5593,"ca_price_per_unit_cad":0.73,"ca_unit":"unit","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per unit, Apo-Mirabegron 50mg ER Tab","ca_price_din":"02564971","ca_per_unit_usd":0.5329,"gap_usd_per_unit":14.03,"ratio_us_to_ca":27.32},{"molecule":"enzalutamide","display":"Enzalutamide","rxcui":"1307298","atc":"L02BB04","atc_l1":"L","atc_l1_name":"Antineoplastic and immunomodulating agents","atc_l2":"L02","atc_l2_name":"Endocrine therapy","brand_examples":["Xtandi"],"us_spend_2024_usd":3400769228.6,"us_units_2024":24915219,"us_benes_2024":35367,"us_avg_cost_per_unit_usd":136.4937,"ca_price_per_unit_cad":7.2989,"ca_unit":"unit","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per unit, Apo-Enzalutamide (Off-Formulary Interchangeable) 40mg Cap","ca_price_din":"02562677","ca_per_unit_usd":5.3284,"gap_usd_per_unit":131.17,"ratio_us_to_ca":25.62},{"molecule":"ticagrelor","display":"Ticagrelor","rxcui":"1116632","atc":"B01AC24","atc_l1":"B","atc_l1_name":"Blood and blood forming organs","atc_l2":"B01","atc_l2_name":"Antithrombotic agents","brand_examples":["Brilinta"],"us_spend_2024_usd":685497436.89,"us_units_2024":94428457,"us_benes_2024":242931,"us_avg_cost_per_unit_usd":7.2594,"ca_price_per_unit_cad":0.396,"ca_unit":"unit","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per unit, Apo-Ticagrelor 90mg Tab","ca_price_din":"02482630","ca_per_unit_usd":0.2891,"gap_usd_per_unit":6.97,"ratio_us_to_ca":25.11},{"molecule":"clobazam","display":"Clobazam","rxcui":"21241","atc":"N05BA09","atc_l1":"N","atc_l1_name":"Nervous system","atc_l2":"N05","atc_l2_name":"Psycholeptics","brand_examples":["Clobazam","Onfi","Sympazan"],"us_spend_2024_usd":56179198.83,"us_units_2024":14108904,"us_benes_2024":22167,"us_avg_cost_per_unit_usd":3.9818,"ca_price_per_unit_cad":0.2197,"ca_unit":"unit","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per unit, Apo-Clobazam 10mg Tab","ca_price_din":"02244638","ca_per_unit_usd":0.1604,"gap_usd_per_unit":3.82,"ratio_us_to_ca":24.82},{"molecule":"lisdexamfetamine dimesylate","display":"Lisdexamfetamine Dimesylate","rxcui":"673579","atc":null,"atc_l1":null,"atc_l1_name":null,"atc_l2":null,"atc_l2_name":null,"brand_examples":["Lisdexamfetamine Dimesylate","Vyvanse"],"us_spend_2024_usd":133327795.51,"us_units_2024":13301508,"us_benes_2024":87492,"us_avg_cost_per_unit_usd":10.0235,"ca_price_per_unit_cad":0.5692,"ca_unit":"unit","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per unit, Apo-Lisdexamfetamine Capsules 10mg Cap","ca_price_din":"02546647","ca_per_unit_usd":0.4155,"gap_usd_per_unit":9.61,"ratio_us_to_ca":24.12},{"molecule":"bromfenac sodium","display":"Bromfenac Sodium","rxcui":"47364","atc":null,"atc_l1":null,"atc_l1_name":null,"atc_l2":null,"atc_l2_name":null,"brand_examples":["Bromfenac Sodium","Bromsite","Prolensa"],"us_spend_2024_usd":69116469.68,"us_units_2024":797124,"us_benes_2024":142709,"us_avg_cost_per_unit_usd":86.7073,"ca_price_per_unit_cad":5.4854,"ca_unit":"mL","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per mL, Apo-Bromfenac (Off-Formulary Interchangeable) 0.07% w/v Oph Sol (With Preservative)","ca_price_din":"02537788","ca_per_unit_usd":4.0045,"gap_usd_per_unit":82.7,"ratio_us_to_ca":21.65},{"molecule":"etanercept","display":"Etanercept","rxcui":"214555","atc":"L04AB01","atc_l1":"L","atc_l1_name":"Antineoplastic and immunomodulating agents","atc_l2":"L04","atc_l2_name":"Immunosuppressants","brand_examples":["Enbrel","Enbrel Mini","Enbrel Sureclick"],"us_spend_2024_usd":3225567875.91,"us_units_2024":1772952,"us_benes_2024":53261,"us_avg_cost_per_unit_usd":1819.3202,"ca_price_per_unit_cad":120.5,"ca_unit":"container","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per container, Erelzi 25mg/0.5mL Inj Sol-0.5mL Pref Syr Pk","ca_price_din":"02462877","ca_per_unit_usd":87.969,"gap_usd_per_unit":1731.35,"ratio_us_to_ca":20.68},{"molecule":"adalimumab","display":"Adalimumab","rxcui":"327361","atc":"L04AB04","atc_l1":"L","atc_l1_name":"Antineoplastic and immunomodulating agents","atc_l2":"L04","atc_l2_name":"Immunosuppressants","brand_examples":["Humira","Humira Pen","Humira(Cf)"],"us_spend_2024_usd":5715863099.68,"us_units_2024":1630312,"us_benes_2024":90349,"us_avg_cost_per_unit_usd":3505.994,"ca_price_per_unit_cad":235.63,"ca_unit":"container","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per container, Abrilada 20mg/0.4mL Inj Sol-0.4mL Pref Syr (Preservative-Free)","ca_price_din":"02511061","ca_per_unit_usd":172.0178,"gap_usd_per_unit":3333.98,"ratio_us_to_ca":20.38},{"molecule":"estradiol","display":"Estradiol","rxcui":"4083","atc":"G03CA03","atc_l1":"G","atc_l1_name":"Genito urinary system and sex hormones","atc_l2":"G03","atc_l2_name":"Sex hormones","brand_examples":["Climara","Divigel","Dotti"],"us_spend_2024_usd":391725707.16,"us_units_2024":229870246,"us_benes_2024":1941472,"us_avg_cost_per_unit_usd":1.7041,"ca_price_per_unit_cad":0.1199,"ca_unit":"unit","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per unit, Lupin-Estradiol 0.5mg Tab","ca_price_din":"02449048","ca_per_unit_usd":0.0875,"gap_usd_per_unit":1.62,"ratio_us_to_ca":19.48},{"molecule":"brexpiprazole","display":"Brexpiprazole","rxcui":"1658314","atc":"N05AX16","atc_l1":"N","atc_l1_name":"Nervous system","atc_l2":"N05","atc_l2_name":"Psycholeptics","brand_examples":["Rexulti"],"us_spend_2024_usd":861392149.79,"us_units_2024":17379109,"us_benes_2024":94695,"us_avg_cost_per_unit_usd":49.5648,"ca_price_per_unit_cad":3.5,"ca_unit":"unit","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per unit, Rexulti 0.25mg Tab","ca_price_din":"02461749","ca_per_unit_usd":2.5551,"gap_usd_per_unit":47.01,"ratio_us_to_ca":19.4},{"molecule":"adalimumab-adbm","display":"Adalimumab-Adbm","rxcui":"2103477","atc":null,"atc_l1":null,"atc_l1_name":null,"atc_l2":null,"atc_l2_name":null,"brand_examples":["Adalimumab-Adbm(Cf)","Adalimumab-Adbm(Cf) Pen","Adalimumab-Adbm(Cf)pen"],"us_spend_2024_usd":60613835.69,"us_units_2024":18844,"us_benes_2024":1579,"us_avg_cost_per_unit_usd":3216.5778,"ca_price_per_unit_cad":235.63,"ca_unit":"container","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per container, Abrilada 20mg/0.4mL Inj Sol-0.4mL Pref Syr (Preservative-Free)","ca_price_din":"02511061","ca_per_unit_usd":172.0178,"gap_usd_per_unit":3044.56,"ratio_us_to_ca":18.7},{"molecule":"metronidazole","display":"Metronidazole","rxcui":"6922","atc":"A01AB17","atc_l1":"A","atc_l1_name":"Alimentary tract and metabolism","atc_l2":"A01","atc_l2_name":"Stomatological preparations","brand_examples":["Flagyl","Metrogel","Metronidazole*"],"us_spend_2024_usd":60051535.87,"us_units_2024":77064262,"us_benes_2024":1633328,"us_avg_cost_per_unit_usd":0.7792,"ca_price_per_unit_cad":0.0572,"ca_unit":"unit","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per unit, Apo-Metronidazole Tablets 250mg Tab","ca_price_din":"00545066","ca_per_unit_usd":0.0418,"gap_usd_per_unit":0.74,"ratio_us_to_ca":18.64},{"molecule":"dasatinib","display":"Dasatinib","rxcui":"475342","atc":"L01EA02","atc_l1":"L","atc_l1_name":"Antineoplastic and immunomodulating agents","atc_l2":"L01","atc_l2_name":"Antineoplastic agents","brand_examples":["Dasatinib","Sprycel"],"us_spend_2024_usd":568525607.84,"us_units_2024":1381481,"us_benes_2024":7778,"us_avg_cost_per_unit_usd":411.5334,"ca_price_per_unit_cad":32.8823,"ca_unit":"unit","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per unit, Apo-Dasatinib (Off-Formulary Interchangeable) 20mg Tab","ca_price_din":"02470705","ca_per_unit_usd":24.0052,"gap_usd_per_unit":387.53,"ratio_us_to_ca":17.14},{"molecule":"bosutinib","display":"Bosutinib","rxcui":"1307619","atc":"L01EA04","atc_l1":"L","atc_l1_name":"Antineoplastic and immunomodulating agents","atc_l2":"L01","atc_l2_name":"Antineoplastic agents","brand_examples":["Bosulif"],"us_spend_2024_usd":235311822.75,"us_units_2024":885859,"us_benes_2024":1981,"us_avg_cost_per_unit_usd":265.6312,"ca_price_per_unit_cad":21.4383,"ca_unit":"unit","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per unit, Reddy-Bosutinib (Off-Formulary Interchangeable) 100mg Tab","ca_price_din":"02560038","ca_per_unit_usd":15.6507,"gap_usd_per_unit":249.98,"ratio_us_to_ca":16.97},{"molecule":"varenicline tartrate","display":"Varenicline Tartrate","rxcui":"636674","atc":null,"atc_l1":null,"atc_l1_name":null,"atc_l2":null,"atc_l2_name":null,"brand_examples":["Chantix","Tyrvaya","Varenicline Tartrate"],"us_spend_2024_usd":204242459.02,"us_units_2024":39106834,"us_benes_2024":256259,"us_avg_cost_per_unit_usd":5.2227,"ca_price_per_unit_cad":0.4618,"ca_unit":"unit","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per unit, Apo-Varenicline 0.5mg Tab","ca_price_din":"02419882","ca_per_unit_usd":0.3371,"gap_usd_per_unit":4.89,"ratio_us_to_ca":15.49},{"molecule":"ustekinumab","display":"Ustekinumab","rxcui":"847083","atc":"L04AC05","atc_l1":"L","atc_l1_name":"Antineoplastic and immunomodulating agents","atc_l2":"L04","atc_l2_name":"Immunosuppressants","brand_examples":["Stelara*"],"us_spend_2024_usd":3378017374.1,"us_units_2024":245388,"us_benes_2024":24754,"us_avg_cost_per_unit_usd":13766.0532,"ca_price_per_unit_cad":1248,"ca_unit":"container","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per container, Wezlana I.V. 130mg/26mL Inj Sol-26mL Vial Pk","ca_price_din":"02544210","ca_per_unit_usd":911.0819,"gap_usd_per_unit":12854.97,"ratio_us_to_ca":15.11},{"molecule":"cyclosporine","display":"Cyclosporine","rxcui":"3008","atc":"L04AD01","atc_l1":"L","atc_l1_name":"Antineoplastic and immunomodulating agents","atc_l2":"L04","atc_l2_name":"Immunosuppressants","brand_examples":["Cequa","Cyclosporine*","Restasis"],"us_spend_2024_usd":1749681664.82,"us_units_2024":205928165,"us_benes_2024":816975,"us_avg_cost_per_unit_usd":8.4966,"ca_price_per_unit_cad":0.7829,"ca_unit":"unit","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per unit, Neoral 10mg Cap","ca_price_din":"02237671","ca_per_unit_usd":0.5715,"gap_usd_per_unit":7.93,"ratio_us_to_ca":14.87},{"molecule":"nilotinib hcl","display":"Nilotinib Hcl","rxcui":"1804015","atc":null,"atc_l1":null,"atc_l1_name":null,"atc_l2":null,"atc_l2_name":null,"brand_examples":["Tasigna"],"us_spend_2024_usd":426961765.33,"us_units_2024":2435739,"us_benes_2024":3054,"us_avg_cost_per_unit_usd":175.2904,"ca_price_per_unit_cad":16.557,"ca_unit":"unit","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per unit, Apo-Nilotinib (Off-Formulary Interchangeable) 150mg Cap","ca_price_din":"02550881","ca_per_unit_usd":12.0872,"gap_usd_per_unit":163.2,"ratio_us_to_ca":14.5},{"molecule":"risperidone","display":"Risperidone","rxcui":"35636","atc":"N05AX08","atc_l1":"N","atc_l1_name":"Nervous system","atc_l2":"N05","atc_l2_name":"Psycholeptics","brand_examples":["Perseris","Risperdal","Risperidone"],"us_spend_2024_usd":178585524.11,"us_units_2024":193264041,"us_benes_2024":495915,"us_avg_cost_per_unit_usd":0.924,"ca_price_per_unit_cad":0.0878,"ca_unit":"unit","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per unit, Apo-Risperidone 0.25mg Tab","ca_price_din":"02282119","ca_per_unit_usd":0.0641,"gap_usd_per_unit":0.86,"ratio_us_to_ca":14.41},{"molecule":"vortioxetine hydrobromide","display":"Vortioxetine Hydrobromide","rxcui":"1439834","atc":null,"atc_l1":null,"atc_l1_name":null,"atc_l2":null,"atc_l2_name":null,"brand_examples":["Trintellix"],"us_spend_2024_usd":392486138.2,"us_units_2024":24438666,"us_benes_2024":100706,"us_avg_cost_per_unit_usd":16.06,"ca_price_per_unit_cad":1.5853,"ca_unit":"unit","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per unit, Apo-Vortioxetine 5mg Tab","ca_price_din":"02552744","ca_per_unit_usd":1.1573,"gap_usd_per_unit":14.9,"ratio_us_to_ca":13.88},{"molecule":"diclofenac potassium","display":"Diclofenac Potassium","rxcui":"81997","atc":null,"atc_l1":null,"atc_l1_name":null,"atc_l2":null,"atc_l2_name":null,"brand_examples":["Cambia","Diclofenac Potassium","Lofena"],"us_spend_2024_usd":89601543.79,"us_units_2024":23059728,"us_benes_2024":160879,"us_avg_cost_per_unit_usd":3.8856,"ca_price_per_unit_cad":0.3937,"ca_unit":"unit","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per unit, Apo-Diclo Rapide (Off-Formulary Interchangeable) 50mg Tab","ca_price_din":"02243433","ca_per_unit_usd":0.2874,"gap_usd_per_unit":3.6,"ratio_us_to_ca":13.52},{"molecule":"denosumab","display":"Denosumab","rxcui":"993449","atc":"M05BX04","atc_l1":"M","atc_l1_name":"Musculo-skeletal system","atc_l2":"M05","atc_l2_name":"Drugs for treatment of bone diseases","brand_examples":["Prolia","Xgeva"],"us_spend_2024_usd":827665924.3,"us_units_2024":481167,"us_benes_2024":288460,"us_avg_cost_per_unit_usd":1720.1214,"ca_price_per_unit_cad":174.49,"ca_unit":"container","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per container, Stoboclo 60mg/mL Inj Sol-1.0mL Pref Syr Pk (Preservative-Free)","ca_price_din":"02560917","ca_per_unit_usd":127.3836,"gap_usd_per_unit":1592.74,"ratio_us_to_ca":13.5},{"molecule":"relugolix","display":"Relugolix","rxcui":"2472778","atc":"L02BX04","atc_l1":"L","atc_l1_name":"Antineoplastic and immunomodulating agents","atc_l2":"L02","atc_l2_name":"Endocrine therapy","brand_examples":["Orgovyx"],"us_spend_2024_usd":484308516.16,"us_units_2024":5564114,"us_benes_2024":28521,"us_avg_cost_per_unit_usd":87.0414,"ca_price_per_unit_cad":9,"ca_unit":"unit","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per unit, Orgovyx 120mg Tab","ca_price_din":"02542137","ca_per_unit_usd":6.5703,"gap_usd_per_unit":80.47,"ratio_us_to_ca":13.25},{"molecule":"cariprazine hcl","display":"Cariprazine Hcl","rxcui":"1721073","atc":null,"atc_l1":null,"atc_l1_name":null,"atc_l2":null,"atc_l2_name":null,"brand_examples":["Vraylar"],"us_spend_2024_usd":1135973310,"us_units_2024":23309776,"us_benes_2024":117573,"us_avg_cost_per_unit_usd":48.7338,"ca_price_per_unit_cad":5.096,"ca_unit":"unit","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per unit, Vraylar 1.5mg Cap","ca_price_din":"02526794","ca_per_unit_usd":3.7203,"gap_usd_per_unit":45.01,"ratio_us_to_ca":13.1},{"molecule":"lenalidomide","display":"Lenalidomide","rxcui":"342369","atc":"L04AX04","atc_l1":"L","atc_l1_name":"Antineoplastic and immunomodulating agents","atc_l2":"L04","atc_l2_name":"Immunosuppressants","brand_examples":["Lenalidomide","Revlimid"],"us_spend_2024_usd":6820366286.1,"us_units_2024":8914893,"us_benes_2024":69222,"us_avg_cost_per_unit_usd":765.0531,"ca_price_per_unit_cad":82.375,"ca_unit":"unit","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per unit, Apo-Lenalidomide 2.5mg Cap","ca_price_din":"02507927","ca_per_unit_usd":60.1365,"gap_usd_per_unit":704.92,"ratio_us_to_ca":12.72},{"molecule":"brivaracetam","display":"Brivaracetam","rxcui":"1739745","atc":"N03AX23","atc_l1":"N","atc_l1_name":"Nervous system","atc_l2":"N03","atc_l2_name":"Antiepileptics","brand_examples":["Briviact*"],"us_spend_2024_usd":219770910.9,"us_units_2024":11449416,"us_benes_2024":15497,"us_avg_cost_per_unit_usd":19.1949,"ca_price_per_unit_cad":2.16,"ca_unit":"unit","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per unit, Apo-Brivaracetam 50mg Tab","ca_price_din":"02538695","ca_per_unit_usd":1.5769,"gap_usd_per_unit":17.62,"ratio_us_to_ca":12.17},{"molecule":"eslicarbazepine acetate","display":"Eslicarbazepine Acetate","rxcui":"1482501","atc":null,"atc_l1":null,"atc_l1_name":null,"atc_l2":null,"atc_l2_name":null,"brand_examples":["Aptiom"],"us_spend_2024_usd":144071383.37,"us_units_2024":3356250,"us_benes_2024":8265,"us_avg_cost_per_unit_usd":42.9263,"ca_price_per_unit_cad":4.935,"ca_unit":"unit","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per unit, Apo-Eslicarbazepine 400mg Tab","ca_price_din":"02537958","ca_per_unit_usd":3.6027,"gap_usd_per_unit":39.32,"ratio_us_to_ca":11.92},{"molecule":"prucalopride succinate","display":"Prucalopride Succinate","rxcui":"2107309","atc":null,"atc_l1":null,"atc_l1_name":null,"atc_l2":null,"atc_l2_name":null,"brand_examples":["Motegrity"],"us_spend_2024_usd":70660851.44,"us_units_2024":4053785,"us_benes_2024":21866,"us_avg_cost_per_unit_usd":17.4308,"ca_price_per_unit_cad":2.0145,"ca_unit":"unit","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per unit, Apo-Prucalopride (Off-Formulary Interchangeable) 1mg Tab","ca_price_din":"02491591","ca_per_unit_usd":1.4707,"gap_usd_per_unit":15.96,"ratio_us_to_ca":11.85},{"molecule":"glatiramer acetate","display":"Glatiramer Acetate","rxcui":"84375","atc":"L03AX13","atc_l1":"L","atc_l1_name":"Antineoplastic and immunomodulating agents","atc_l2":"L03","atc_l2_name":"Immunostimulants","brand_examples":["Copaxone","Glatiramer Acetate","Glatopa"],"us_spend_2024_usd":411553409.27,"us_units_2024":1718434,"us_benes_2024":14455,"us_avg_cost_per_unit_usd":239.4933,"ca_price_per_unit_cad":27.8587,"ca_unit":"container","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per container, Glatiramer Acetate Injection 20mg/mL Inj Sol Pref Syr-1mL Pk","ca_price_din":"02541440","ca_per_unit_usd":20.3378,"gap_usd_per_unit":219.16,"ratio_us_to_ca":11.78},{"molecule":"doxepin hcl","display":"Doxepin Hcl","rxcui":"203179","atc":null,"atc_l1":null,"atc_l1_name":null,"atc_l2":null,"atc_l2_name":null,"brand_examples":["Doxepin HCl*","Silenor","Zonalon"],"us_spend_2024_usd":66175426.12,"us_units_2024":78184645,"us_benes_2024":292471,"us_avg_cost_per_unit_usd":0.8464,"ca_price_per_unit_cad":0.1019,"ca_unit":"unit","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per unit, Apo-Doxepin 10mg Cap","ca_price_din":"02049996","ca_per_unit_usd":0.0744,"gap_usd_per_unit":0.77,"ratio_us_to_ca":11.38},{"molecule":"lamotrigine","display":"Lamotrigine","rxcui":"28439","atc":"N03AX09","atc_l1":"N","atc_l1_name":"Nervous system","atc_l2":"N03","atc_l2_name":"Antiepileptics","brand_examples":["Lamictal","Lamictal (Orange)","Lamictal ODT"],"us_spend_2024_usd":221328775.36,"us_units_2024":386936326,"us_benes_2024":679546,"us_avg_cost_per_unit_usd":0.572,"ca_price_per_unit_cad":0.0698,"ca_unit":"unit","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per unit, Apo-Lamotrigine 25mg Tab","ca_price_din":"02245208","ca_per_unit_usd":0.051,"gap_usd_per_unit":0.52,"ratio_us_to_ca":11.22},{"molecule":"quetiapine fumarate","display":"Quetiapine Fumarate","rxcui":"221153","atc":null,"atc_l1":null,"atc_l1_name":null,"atc_l2":null,"atc_l2_name":null,"brand_examples":["Quetiapine Fumarate","Quetiapine Fumarate ER","Seroquel"],"us_spend_2024_usd":208919256.63,"us_units_2024":540975651,"us_benes_2024":1488933,"us_avg_cost_per_unit_usd":0.3862,"ca_price_per_unit_cad":0.0494,"ca_unit":"unit","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per unit, AG-Quetiapine 25mg Tab","ca_price_din":"02475979","ca_per_unit_usd":0.0361,"gap_usd_per_unit":0.35,"ratio_us_to_ca":10.7},{"molecule":"eltrombopag olamine","display":"Eltrombopag Olamine","rxcui":"735651","atc":null,"atc_l1":null,"atc_l1_name":null,"atc_l2":null,"atc_l2_name":null,"brand_examples":["Promacta"],"us_spend_2024_usd":672379160.6,"us_units_2024":1608219,"us_benes_2024":6666,"us_avg_cost_per_unit_usd":418.0893,"ca_price_per_unit_cad":55.25,"ca_unit":"unit","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per unit, Apo-Eltrombopag (Off-Formulary Interchangeable) 25mg Tab","ca_price_din":"02506742","ca_per_unit_usd":40.3344,"gap_usd_per_unit":377.75,"ratio_us_to_ca":10.37},{"molecule":"aripiprazole","display":"Aripiprazole","rxcui":"89013","atc":"N05AX12","atc_l1":"N","atc_l1_name":"Nervous system","atc_l2":"N05","atc_l2_name":"Psycholeptics","brand_examples":["Abilify","Abilify Asimtufii","Abilify Maintena"],"us_spend_2024_usd":967982256.16,"us_units_2024":160539016,"us_benes_2024":684239,"us_avg_cost_per_unit_usd":6.0296,"ca_price_per_unit_cad":0.8092,"ca_unit":"unit","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per unit, Apo-Aripiprazole 2mg Tab","ca_price_din":"02471086","ca_per_unit_usd":0.5907,"gap_usd_per_unit":5.44,"ratio_us_to_ca":10.21},{"molecule":"rivastigmine","display":"Rivastigmine","rxcui":"183379","atc":"N06DA03","atc_l1":"N","atc_l1_name":"Nervous system","atc_l2":"N06","atc_l2_name":"Psychoanaleptics","brand_examples":["Exelon","Rivastigmine"],"us_spend_2024_usd":79397968.49,"us_units_2024":16556760,"us_benes_2024":82282,"us_avg_cost_per_unit_usd":4.7955,"ca_price_per_unit_cad":0.6514,"ca_unit":"unit","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per unit, Jamp Rivastigmine 3mg Cap","ca_price_din":"02485370","ca_per_unit_usd":0.4755,"gap_usd_per_unit":4.32,"ratio_us_to_ca":10.09},{"molecule":"rotigotine","display":"Rotigotine","rxcui":"616739","atc":"N04BC09","atc_l1":"N","atc_l1_name":"Nervous system","atc_l2":"N04","atc_l2_name":"Anti-parkinson drugs","brand_examples":["Neupro"],"us_spend_2024_usd":90068151.36,"us_units_2024":3263791,"us_benes_2024":14920,"us_avg_cost_per_unit_usd":27.5962,"ca_price_per_unit_cad":3.828,"ca_unit":"package","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per package, Neupro 2mg/24hr Trans Patch","ca_price_din":"02403900","ca_per_unit_usd":2.7946,"gap_usd_per_unit":24.8,"ratio_us_to_ca":9.87},{"molecule":"imatinib mesylate","display":"Imatinib Mesylate","rxcui":"284924","atc":null,"atc_l1":null,"atc_l1_name":null,"atc_l2":null,"atc_l2_name":null,"brand_examples":["Gleevec","Imatinib Mesylate"],"us_spend_2024_usd":219420577.2,"us_units_2024":6061132,"us_benes_2024":16553,"us_avg_cost_per_unit_usd":36.2013,"ca_price_per_unit_cad":5.2079,"ca_unit":"unit","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per unit, Ach-Imatinib 100mg Tab","ca_price_din":"02490986","ca_per_unit_usd":3.8019,"gap_usd_per_unit":32.4,"ratio_us_to_ca":9.52},{"molecule":"prednisone","display":"Prednisone","rxcui":"8640","atc":"A07EA03","atc_l1":"A","atc_l1_name":"Alimentary tract and metabolism","atc_l2":"A07","atc_l2_name":"Antidiarrheals","brand_examples":["Prednisone","Prednisone Intensol","Rayos"],"us_spend_2024_usd":81469404.69,"us_units_2024":539038703,"us_benes_2024":7659993,"us_avg_cost_per_unit_usd":0.1511,"ca_price_per_unit_cad":0.022,"ca_unit":"unit","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per unit, Apo-Prednisone 5mg Tab","ca_price_din":"00312770","ca_per_unit_usd":0.0161,"gap_usd_per_unit":0.14,"ratio_us_to_ca":9.39},{"molecule":"amitriptyline hcl","display":"Amitriptyline Hcl","rxcui":"203168","atc":null,"atc_l1":null,"atc_l1_name":null,"atc_l2":null,"atc_l2_name":null,"brand_examples":["Amitriptyline HCl"],"us_spend_2024_usd":54717091.64,"us_units_2024":262587495,"us_benes_2024":848297,"us_avg_cost_per_unit_usd":0.2084,"ca_price_per_unit_cad":0.0305,"ca_unit":"unit","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per unit, Jamp-Amitriptyline 10mg Tab","ca_price_din":"02457679","ca_per_unit_usd":0.0223,"gap_usd_per_unit":0.19,"ratio_us_to_ca":9.35},{"molecule":"levothyroxine sodium","display":"Levothyroxine Sodium","rxcui":"40144","atc":"H03AA01","atc_l1":"H","atc_l1_name":"Systemic hormonal preparations","atc_l2":"H03","atc_l2_name":"Thyroid therapy","brand_examples":["Ermeza","Euthyrox","Levo-T"],"us_spend_2024_usd":842684081.24,"us_units_2024":3319775775,"us_benes_2024":10236905,"us_avg_cost_per_unit_usd":0.2538,"ca_price_per_unit_cad":0.0373,"ca_unit":"unit","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per unit, Apo-Levothyroxine 0.05mg Tab","ca_price_din":"02550717","ca_per_unit_usd":0.0272,"gap_usd_per_unit":0.23,"ratio_us_to_ca":9.33},{"molecule":"empagliflozin","display":"Empagliflozin","rxcui":"1545653","atc":"A10BK03","atc_l1":"A","atc_l1_name":"Alimentary tract and metabolism","atc_l2":"A10","atc_l2_name":"Drugs used in diabetes","brand_examples":["Jardiance"],"us_spend_2024_usd":11435997421,"us_units_2024":604181682,"us_benes_2024":2543331,"us_avg_cost_per_unit_usd":18.9281,"ca_price_per_unit_cad":2.8868,"ca_unit":"unit","ca_price_source":"Ontario Drug Benefit formulary, lowest Drug Benefit Price per unit, Jardiance 10mg Tab","ca_price_din":"02443937","ca_per_unit_usd":2.1075,"gap_usd_per_unit":16.82,"ratio_us_to_ca":8.98}],"caveat":"US amounts are gross of confidential manufacturer rebates and overstate net price by an unknown share."}