{"project":"canada-drug-prices","source":"US: CMS Medicare Part D Spending by Drug 2024 (Overall rows). Canada: Ontario Drug Benefit e-formulary lowest Drug Benefit Price per unit.","vintage":"US 2024 (published 2026-06-25); Canada retrieved 2026-10-10","fx":{"usd_cad_2024":1.3698,"source":"Bank of Canada daily average 2024"},"counts":{"molecules_total":484,"molecules_matched":194,"rxcui_resolved":447},"insights":{"molecules_matched":194,"molecules_total":484,"molecules_quarantined":16,"quarantine":{"clonidine":"CMS row is the transdermal patch; ODB comparator is oral tablets","epinephrine":"CMS per-unit mixes auto-injectors (Auvi-Q, EpiPen) with ampules; ODB comparator is the cheapest ampule","ipratropium bromide":"CMS dosage unit mixes per-inhaler (Atrovent HFA) and per-vial (nebulizer solution)","tiotropium bromide":"CMS dosage unit mixes per-capsule (HandiHaler) and per-inhaler (Respimat)","beclomethasone dipropionate":"CMS mixes nasal sprays and inhalers; ODB cheapest match is a topical ointment","budesonide":"CMS per-unit mixes oral capsules, inhalers, and oral suspension","lanreotide acetate":"syringe dose mix (60/90/120mg) cannot be matched to the single ODB biosimilar product","insulin lispro-aabc":"Lyumjev (ultra-rapid) matched ODB insulin lispro (Humalog/Admelog); different products","semaglutide":"CMS per-unit mixes tablets (Rybelsus), Ozempic pens, and Wegovy pens","risankizumab-rzaa":"dose mix (75mg syringe vs 150mg pen vs on-body injector) cannot be matched to the single ODB product","infliximab":"CMS is IV vials; ODB comparator is the subcutaneous pen (Remsima SC); different routes","buprenorphine":"CMS mixes patch, buccal film, and depot injection; ODB lists only the depot syringe","buprenorphine hcl":"CMS is oral/sublingual; ODB lists only the Sublocade depot syringe","ondansetron hcl":"CMS is oral tablets; ODB query returned only the injectable (tablets sit under a different generic string)","enoxaparin sodium":"cannot determine whether the CMS dosage unit is per mL or per syringe","fluticasone propionate":"CMS dosage unit mixes inhalers and nasal spray with unclear per-unit definitions"},"max_ratio":66.73,"max_ratio_molecule":"Rivaroxaban","matched_spend_usd":125535078912.25,"median_ratio":4.4,"fx_usd_cad_2024":1.3698,"us_vintage":"2024, published 2026-06-25","ca_source":"Ontario Drug Benefit e-formulary, retrieved 2026-10-10","caveat":"US amounts are gross of confidential manufacturer rebates and overstate net US prices by an unknown share."},"caveat":"US amounts are gross of confidential manufacturer rebates and overstate net price by an unknown share. State this on every price comparison."}